Copper-Catalyzed Direct Coupling of Unprotected Propargylic Alcohols with P(O)H Compounds: Access to Allenylphosphoryl Compounds under Ligand- and Base-Free Conditions

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• 作者：Gaobo Hu ; Changkai Shan ; Weizhu Chen ; Pengxiang Xu ; Yuxing Gao ; Yufen Zhao
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：December 2, 2016
• 年：2016
• 卷：18
• 期：23
• 页码：6066-6069
• 全文大小：375K
• ISSN：1523-7052

文摘

The first facile and efficient copper-catalyzed direct C–P cross-coupling of unprotected propargylic alcohols with P(O)H compounds has been developed, providing a general, one-step approach to construct valuable allenylphosphoryl frameworks with operational simplicity and high step- and atom-economy under ligand-, base-, and additive-free conditions.