Stepwise-Acid-Active Multifunctional Mesoporous Silica Nanoparticles for Tumor-Specific Nucleus-Targeted Drug Delivery

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• 作者：Ze-Yong Li ; Yun Liu ; Jing-Jing Hu ; Qi Xu ; Li-Han Liu ; Hui-Zhen Jia ; Wei-Hai Chen ; Qi Lei ; Lei Rong ; Xian-Zheng Zhang
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2014
• 出版时间：August 27, 2014
• 年：2014
• 卷：6
• 期：16
• 页码：14568-14575
• 全文大小：401K
• ISSN：1944-8252

文摘

In this paper, a novel stepwise-acid-active multifunctional mesoporous silica nanoparticle (MSN-^SATAT&^DMAK₁₁) was developed as a drug carrier. The MSN-^SATAT&^DMAK₁₁ is able to reverse its surface charge from negative to positive in the mildly acidic tumor extracellular environment. Then, the fast endo/lysosomal escape and subsequent nucleus targeting as well as intranuclear drug release can be realized after cellular internalization. Because of the difference in acidity between the tumor extracellular environment and that of endo/lysosomes, this multifunctional MSN-^SATAT&^DMAK₁₁ exhibits a stepwise-acid-active drug delivery with a tumor-specific nucleus-targeted property.

Keywords:

mesoporous silica nanoparticle; drug release; stepwise-acid-activation; tumor-specificity; nucleus-targeting