Enantioselective Functionalization of Inactive sp3 C鈥揌 Bonds Remote to Functional Group by Metal/Organo Cooperative Catalysis
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- 作者：Xiao-Le Zhou ; Pu-Sheng Wang ; Da-Wei Zhang ; Peng Liu ; Cheng-Ming Wang ; Liu-Zhu Gong
- 刊名：Organic Letters
- 出版年：2015
- 出版时间：October 16, 2015
- 年：2015
- 卷：17
- 期：20
- 页码：5120-5123
- 全文大小：361K
- ISSN：1523-7052
文摘
A metal/organo cooperative catalysis to enable the enantioselective functionalization of inactive C鈥揌 bonds 纬 to the formyl group in aliphatic aldehydes has been established. Instead of using enals as substrates in traditional organocatalytic cyclization reactions, the aliphatic aldehydes directly participated in [4 + 2] cyclization with quinone derivatives exploiting molecular oxygen as oxidants to afford optically active cyclic molecules with excellent levels of enantioselectivity. This method features a combination of pot, step, and atom economy.