Transition-Metal-Free Sonogashira-Type Cross-Coupling of Alkynes with Fluoroarenes

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• 作者：Guanyi Jin ; Xuxue Zhang ; Song Cao
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：June 21, 2013
• 年：2013
• 卷：15
• 期：12
• 页码：3114-3117
• 全文大小：237K
• 年卷期：v.15,no.12(June 21, 2013)
• ISSN：1523-7052

文摘

A novel, inexpensive, and efficient palladium-, copper-, ligand-, and amine-free Sonogashira-type cross-coupling reaction of terminal alkynes with unreactive aryl fluorides in the presence of sodium, sodium methoxide, and calcium hydroxide under the assistance of a Grignard reagent was developed. A plausible mechanism was also suggested.