Highly Chemoselective Rauhut鈥揅urrier Reaction between Maleimides and Enones and Dual Phosphine-Mediated One-Pot Synthesis of Bicyclic and Polycyclic Skeletons

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• 作者：Rong Zhou ; Jianfang Wang ; Jia Yu ; Zhengjie He
• 刊名：Journal of Organic Chemistry
• 出版年：2013
• 出版时间：November 1, 2013
• 年：2013
• 卷：78
• 期：21
• 页码：10596-10604
• 全文大小：368K
• 年卷期：v.78,no.21(November 1, 2013)
• ISSN：1520-6904

文摘

A highly chemoselective phosphine-catalyzed Rauhut鈥揅urrier reaction between maleimides and enones has been realized under very mild conditions, affording the corresponding cross-coupling products in moderate to excellent yields. On the basis of this reaction, an efficient dual phosphine-mediated one-pot synthesis of bicyclic and polycyclic compounds containing a cyclopenta[c]pyrrole skeleton has been accordingly developed, which features a tandem sequence of intermolecular Rauhut鈥揅urrier reaction and intramolecular Wittig reaction.