Simultaneous Reduction and Surface Functionalization of Graphene Oxide for Hydroxyapatite Mineralization

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• 作者：Hongyan Liu ; Pinxian Xi ; Guoqiang Xie ; Yanjun Shi ; Fengping Hou ; Liang Huang ; Fengjuan Chen ; Zhengzhi Zeng ; Changwei Shao ; Jun Wang
• 刊名：The Journal of Physical Chemistry C
• 出版年：2012
• 出版时间：February 9, 2012
• 年：2012
• 卷：116
• 期：5
• 页码：3334-3341
• 全文大小：527K
• 年卷期：v.116,no.5(February 9, 2012)
• ISSN：1932-7455

文摘

In this study, we present the synthesis of reduced graphene oxide/hydroxyapatite (RGO/HA) hybrid materials by an environmental-friendly route. Graphene oxide (GO) was first simultaneously reduced and surface functionalized by one-step oxidative polymerization of dopamine (PDA). The bioinspired surface was further used for biomimetic mineralization of hydroxyapatite. When incubated in a simulated body fluid (SBF), the PDA layer enabled efficient interaction between the RGO surface and the mineral ions to improve the bioactivity, promoted the formation of the HA nanoparticles. A detailed structural and morphological characterization of the mineralized composite was performed. The HA-based hybrid materials exhibited no cytotoxic effect on L929 fibroblast cells, showing potential capacity of being a scaffold material for bone tissue regeneration and implantation. This facile strategy also can be a useful platform for other RGO-based nanocomposites.