An Efficient Approach for Monofluorination via Aqueous Fluorolactonization Reaction of 2,3-Allenoic Acids with Selectfluor

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• 作者：Chao Zhou ; Zhichao Ma ; Zhenhua Gu ; Chunling Fu ; Shengming Ma
• 刊名：Journal of Organic Chemistry
• 出版年：2008
• 出版时间：January 18, 2008
• 年：2008
• 卷：73
• 期：2
• 页码：772 - 774
• 全文大小：47K
• 年卷期：v.73,no.2(January 18, 2008)
• ISSN：1520-6904

文摘

We have developed a convenient method for the efficientmonofluorination via the electrophilic fluorocyclization reaction of 2,3-allenoic acids with Selectfluor in MeCN in thepresence of 10 equiv of H₂O or even in pure water to afford-fluorobutenolides in moderate to high yields.