Highly Selective and Sensitive 1-Amino BODIPY-Based Red Fluorescent Probe for Thiophenols with High Off-to-On Contrast Ratio

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• 作者：Xiangmin Shao ; Ruixue Kang ; Yuanlin Zhang ; Zhentao Huang ; Fangfang Peng ; Jian Zhang ; Yue Wang ; Fuchao Pan ; Weijuan Zhang ; Weili Zhao
• 刊名：Analytical Chemistry
• 出版年：2015
• 出版时间：January 6, 2015
• 年：2015
• 卷：87
• 期：1
• 页码：399-405
• 全文大小：451K
• ISSN：1520-6882

文摘

A highly selective and sensitive turn-on red fluorescent 1-amino BODIPY-based probe (where BODIPY denotes indole-based boron-dipyrromethene) with high off-to-on contrast ratio has been developed. The probe displayed selective response to thiophenols over aliphatic thiols. Probe 1 is promising for the quantitative detection of thiophenol with a linear response from 6 脳 10^鈥? M to 1 脳 10^鈥? M, and the detection limit for thiophenol (PhSH) reaches 4 脳 10^鈥? M measured in acetonitrile/PBS buffer. The detection limit could be improved to 37 nM (detection limit to 4 ppb) in water when 1% Tween 20 was used to assist the dissolvation of probe 1 in water. Probe 1 is also a useful fluorescent probe for detecting thiophenols in living cells in red emission, which may greatly improve the detectable sensitivity.