Persistent Organic Nanopores Amenable to Structural and Functional Tuning

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• 作者：Xiaoxi Wei ; Guoqing Zhang ; Yi Shen ; Yulong Zhong ; Rui Liu ; Na Yang ; Fayez Y. Al-mkhaizim ; Mark A. Kline ; Lan He ; Minfeng Li ; Zhong-Lin Lu ; Zhifeng Shao ; Bing Gong
• 刊名：Journal of the American Chemical Society
• 出版年：2016
• 出版时间：March 2, 2016
• 年：2016
• 卷：138
• 期：8
• 页码：2749-2754
• 全文大小：554K
• ISSN：1520-5126

文摘

Rigid macrocycles 2, which share a hybrid backbone and the same set of side chains while having inner cavities with different inward-pointing functional groups, undergo similar nanotubular assembly as indicated by multiple techniques including ¹H NMR, fluorescence spectroscopy, and atomic force microscopy. The formation of tubular assemblies containing subnanometer pores is also attested by the different transmembrane ion-transport behavior observed for these macrocycles. Vesicle-based stopped-flow kinetic assay and single-channel electrophysiology with planar lipid bilayers show that the presence of an inward-pointing functional (X) group in the inner cavity of a macrocyclic building block exerts a major influence on the transmembrane ion-transporting preference of the corresponding self-assembling pore. Self-assembling pores with inward-pointing amino and methyl groups possess the surprising and remarkable capability of rejecting protons but are conducive to transporting larger ions. The inward-pointing groups also resulted in transmembrane pores with a different extent of positive electrostatic potentials, leading to channels having different preferences for transporting chloride ion. Results from this work demonstrate that synthetic modification at the molecular level can profoundly impact the property of otherwise structurally persistent supramolecular assemblies, with both expected tunability and suprisingly unusual behavior.