Sulfhydryl-Modified Fe3O4@SiO2 Core/Shell Nanocomposite: Synthesis and Toxicity Assessment in Vitro

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• 作者：Xueyi Guo ; Fangfang Mao ; Weijia Wang ; Ying Yang ; Zhiming Bai
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2015
• 出版时间：July 15, 2015
• 年：2015
• 卷：7
• 期：27
• 页码：14983-14991
• 全文大小：654K
• ISSN：1944-8252

文摘

The objectives of this study are to prepare sulfhydryl-modified Fe₃O₄@SiO₂ core/shell magnetic nanocomposites, assess their toxicity in vitro, and explore their potential application in the biomedical fields. Fe₃O₄ nanoparticles synthesized by facile solvothermal method were coated with SiO₂ via the St枚ber method and further modified by the meso-2,3-dimercaptosuccinic acid (DMSA) to prepare Fe₃O₄@SiO₂@DMSA nanoparticles. The morphology, structure, functional groups, surface charge, and magnetic susceptibility of the nanoparticles were characterized by transmission electron microscopy, X-ray diffraction, Fourier transform infrared spectrometry, X-ray photoelectron spectroscopy, zeta potential analysis, dynamic laser scattering, and vibrating sample magnetometer. Cytotoxicity tests and hemolysis assay were also carried out. Experimental results show that the toxicity of sulfhydryl-modified Fe₃O₄@SiO₂ core/shell nanoparticles in mouse fibroblast (L-929) cell lines is between grade 0 and grade 1, and the material lacks hemolytic activity, indicating good biocompatibility of this Fe₃O₄@SiO₂@DMSA nanocomposite, which is suitable for further application in biochemical fields.