Iron-Catalyzed Radical [2 + 2 + 2] Annulation of Benzene-Linked 1,7-Enynes with Aldehydes: Fused Pyran Compounds

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• 作者：Leiyang Lv ; Zhiping Li
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：May 6, 2016
• 年：2016
• 卷：18
• 期：9
• 页码：2264-2267
• 全文大小：405K
• 年卷期：0
• ISSN：1523-7052

文摘

An iron-catalyzed radical [2 + 2 + 2] annulation of benzene-linked 1,7-enynes with aldehydes has been developed. With this method, a variety of fused [6.6.6] pyran molecules are built in an efficient and selective manner. The aldehydic radical-mediated strategy exhibits a particularly attractive dual role, which triggers and terminates the domino cyclization.