Cytotoxic Hydrolyzable Tannins from Balanophora japonica

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• 作者：Zhi-Hong Jiang ; Xiao-Yun Wen ; Takashi Tanaka ; Shao-Yu Wu ; Zhongqiu Liu ; Hiromi Iwata ; Yoko Hirose ; Shuguang Wu ; Isao Kouno
• 刊名：Journal of Natural Products
• 出版年：2008
• 出版时间：April 2008
• 年：2008
• 卷：71
• 期：4
• 页码：719 - 723
• 全文大小：131K
• 年卷期：v.71,no.4(April 2008)
• ISSN：1520-6025

文摘

Four hydrolyzable tannins named balanophotannins D−G (1–4) were isolated from the aerial parts of the parasitic plant Balanophora japonica. Their structures were characterized on the basis of spectroscopic and chemical evidence. Balanophotannins D−G contain an oxidized hexahydroxydiphenoyl (HHDP) group. The absolute configurations of balanophotannins D (1) and F (3) were determined via the PGME method. Balanophotannin E (2) showed cytotoxicity to Hep G2 cancer cells with an IC₅₀ value of 4.22 µM.