Cembranoids from the Soft Coral Sinularia rigida with Antifouling Activities

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• 作者：Daowan Lai ; Zhufeng Geng ; Zhiwei Deng ; Leen van Ofwegen ; Peter Proksch ; Wenhan Lin
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2013
• 出版时间：May 15, 2013
• 年：2013
• 卷：61
• 期：19
• 页码：4585-4592
• 全文大小：360K
• 年卷期：v.61,no.19(May 15, 2013)
• ISSN：1520-5118

文摘

Chemical examination of the soft coral Sinularia rigida resulted in the isolation of 12 new cembranoids, namely, sinulariols T鈥揨₅ (1鈥?b>12), together with a known analogue, 13. Their structures were determined on the basis of 1D and 2D NMR (COSY, HSQC, HMBC, and NOESY) spectroscopic analyses in association with MS and IR data. Compounds 7 and 13 showed potent antifouling activity for the inhibition against the barnacle Balanus amphitrite and moderate inhibition against Bugula neritina. The primary structure鈥揳ctivity relationship is discussed.

Keywords:

soft coral; Sinularia rigida; sinulariols T鈭抁₅; structural elucidation; antifouling activity