Feasibility of Ionic Liquids as Extractants for Selective Separation of Vitamin D3 and Tachysterol3 by Solvent Extraction

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• 作者：Ruisi Liang ; Zongbi Bao ; Baogen Su ; Huabin Xing ; Qiwei Yang ; Yiwen Yang ; Qilong Ren
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2013
• 出版时间：April 10, 2013
• 年：2013
• 卷：61
• 期：14
• 页码：3479-3487
• 全文大小：432K
• 年卷期：v.61,no.14(April 10, 2013)
• ISSN：1520-5118

文摘

A selective separation of vitamin D₃ and tachysterol₃ by solvent extraction with 7 organic solvents and 11 ionic liquids (ILs) has been reported. Among organic solvents sulfolane showed optimal extraction performance, giving only a selectivity of 1.44 for tachysterol₃ over vitamin D₃. ILs with unsaturated bonds demonstrated high selectivity probably due to their different 蟺鈥撓€ interactions with the two compounds. A pyrrolidinium-based ionic liquid, for example, [BMPr][NTf₂], provided the highest selectivity up to 1.77. Acceptable selectivity and distribution coefficients were observed by a combination of organic solvents and ILs as extracting agents. In this work, the effects of concentrations, anions, cations, and substituent of ILs were investigated, which may provide a rational strategy for the design of novel ILs for extractive separation of structural analogues. The purification and recovery of vitamin D₃ via continuous multistage extractions were simulated, indicating that IL-based liquid鈥搇iquid extraction might be superior to traditional organic solvents in practical production.

Keywords:

vitamin D₃; tachysterol₃; liquid鈭抣iquid extraction; organic solvents; ionic liquids; continuous multistage extraction