Selective Synthesis of Indoles by Cobalt(III)-Catalyzed C–H/N–O Functionalization with Nitrones

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• 作者：Hui Wang ; Marc Moselage ; María J. González ; Lutz Ackermann
• 刊名：ACS Catalysis
• 出版年：2016
• 出版时间：April 1, 2016
• 年：2016
• 卷：6
• 期：4
• 页码：2705-2709
• 全文大小：502K
• ISSN：2155-5435

文摘

The redox-neutral annulation of alkynes by differently decorated nitrones set the stage for a step-economical access to indoles with ample substrate scope. The redox-neutral C–H/N–O functionalization process proceeded through kinetically relevant C–H activation by carboxylate assistance, and displayed an excellent site- and regio-selectivity with unsymmetrical nitrones and alkynes.