A Concise Synthesis of (?)-Lasonolide A

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• 作者：Barry M. Trost ; Craig E. Stivala ; Kami L. Hull ; Audris Huang ; Daniel R. Fandrick
• 刊名：Journal of the American Chemical Society
• 出版年：2014
• 出版时间：January 8, 2014
• 年：2014
• 卷：136
• 期：1
• 页码：88-91
• 全文大小：289K
• ISSN：1520-5126

文摘

Lasonolide A is a novel polyketide displaying potent anticancer activity across a broad range of cancer cell lines. Here, an enantioselective convergent total synthesis of the (鈭?-lasonolide A in 16 longest linear and 34 total steps is described. This approach significantly reduces the step count compared to other known syntheses. The synthetic strategy utilizes alkyne-bearing substrates as core building blocks and is highlighted by stitching together two similarly complex halves via a key Ru-catalyzed alkene鈥揳lkyne coupling and macrolactionization.