Nonsteroidal Androgen Receptor Ligands: Versatile Syntheses and Biological Data
详细信息 查看全文
- 作者：Greta Varchi ; Andrea Guerrini ; Anna Tesei ; Giovanni Brigliadori ; Carlo Bertucci ; Marzia Di Donato ; Gabriella Castoria
- 刊名：ACS Medicinal Chemistry Letters
- 出版年：2012
- 出版时间：June 14, 2012
- 年：2012
- 卷：3
- 期：6
- 页码：454-458
- 全文大小：345K
- 年卷期：v.3,no.6(June 14, 2012)
- ISSN：1948-5875
文摘
We report herein a stereoselective and straightforward methodology for the synthesis of new androgen receptor ligands with (anti)-agonistic activities. Oxygen鈥搉itrogen replacement in bicalutamide-like structures paves the way to the disclosure of a new class of analogues, including cyclized/nitrogen-substituted derivatives, with promising antiandrogen (or anabolic) activity.