Photocontrolled Nuclear-Targeted Drug Delivery by Single Component Photoresponsive Fluorescent Organic Nanoparticles of Acridin-9-Methanol
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- 作者：Avijit Jana ; Biswajit Saha ; Deb Ranjan Banerjee ; Sudip Kumar Ghosh ; Kim Truc Nguyen ; Xing Ma ; Qiuyu Qu ; Yanli Zhao ; N. D. Pradeep Singh
- 刊名：Bioconjugate Chemistry
- 出版年：2013
- 出版时间：November 20, 2013
- 年：2013
- 卷：24
- 期：11
- 页码：1828-1839
- 全文大小：864K
- 年卷期：v.24,no.11(November 20, 2013)
- ISSN：1520-4812
文摘
We report for the first time an organic nanoparticle based nuclear-targeted photoresponsive drug delivery system (DDS) for regulated anticancer drug release. Acridin-9-methanol fluorescent organic nanoparticles used in this DDS performed three important roles: (i) 鈥硁uclear-targeted nanocarrier鈥?for drug delivery, (ii) 鈥硃hototrigger鈥?for regulated drug release, and (iii) fluorescent chromophore for cell imaging. In vitro biological studies reveal acridin-9-methanol nanoparticles of 60 nm size to be very efficient in delivering the anticancer drug chlorambucil into the target nucleus, killing the cancer cells upon irradiation. Such targeted organic nanoparticles with good biocompatibility, cellular uptake property, and efficient photoregulated drug release ability will be of great benefit in the field of targeted intracellular controlled drug release.