MRI Detection of VEGFR2 in Vivo Using a Low Molecular Weight Peptoid−(Gd)8-Dendron for Targeting

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• 作者：Luis M. De Len-Rodrguez ; Angelo Lubag ; D. Gomika Udugamasooriya ; Bettina Proneth ; Rolf A. Brekken ; Xiankai Sun ; Thomas Kodadek ; A. Dean Sherry
• 刊名：Journal of the American Chemical Society
• 出版年：2010
• 出版时间：September 22, 2010
• 年：2010
• 卷：132
• 期：37
• 页码：12829-12831
• 全文大小：152K
• 年卷期：v.132,no.37(September 22, 2010)
• ISSN：1520-5126

文摘

The synthesis of a polylysine dendron containing eight GdDOTA units conjugated to a peptoid dimer known to have a high affinity for the vascular endothelial growth factor receptor 2 (VEGFR2) is described. This simple low molecular weight system with a molecular r₁ relaxivity of 48 mM⁻¹ s⁻¹ is shown to enhance MR images of tumors grown in mice in vivo.