Shieldable Tumor Targeting Based on pH Responsive Self-Assembly/Disassembly of Gold Nanoparticles

详细信息    查看全文

• 作者：Zhiqing Tian ; Chengling Yang ; Wei Wang ; Zhi Yuan
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2014
• 出版时间：October 22, 2014
• 年：2014
• 卷：6
• 期：20
• 页码：17865-17876
• 全文大小：649K
• ISSN：1944-8252

文摘

A new approach to shield/deshield ligands for controllable tumor targeting was reported, which was based on amphiphilic self-assembly and disassembly of gold nanoparticles (Au NPs). Thanks to the excellent pH response of the system, glycyrrhetinic acid (GA) ligands can be buried inside the Au NPs鈥?assembly at normal tissue pH (pH 7.4), while exposed when the nanostructure is disassembled at tumor extracellular pH (pHe 6.8). Hydrophobic GA molecules not only acted as ligands targeting tumor cells but also provided the major interparticle attractive force for Au NPs鈥?assembling. An ordered assembly of Au NPs with regular shape, proper size and ultrasharp pH sensitivity (螖pH 鈭?0.2) was achieved by fine-tuning of materials modified on Au NPs. Mechanism studies for assembly and disassembly of Au NPs indicated the possibility of a GA shield when the assembly formed, which was further demonstrated by bovine serum albumin absorption and cellular uptake. The assembly/disassembly process was reversible within extrinsic pH changes, which provides a perspective for reversible tumor targeting.

Keywords:

tumor targeting; self-assembly; gold nanoparticle; pH-responsive; drug delivery