Salinazinones A and B: Pyrrolidinyl-Oxazinones from Solar Saltern-Derived Streptomyces sp. KMF-004
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- 作者：Min Cheol Kim ; Jung Hwan Lee ; Bora Shin ; Lalita Subedi ; Jin Wook Cha ; Jin-Soo Park ; Dong-Chan Oh ; Sun Yeou Kim ; Hak Cheol Kwon
- 刊名：Organic Letters
- 出版年：2015
- 出版时间：October 16, 2015
- 年：2015
- 卷：17
- 期：20
- 页码：5024-5027
- 全文大小：275K
- ISSN：1523-7052
文摘
Salinazinones A (1) and B (2), two unprecedented pyrrolidinyl-oxazinones, were isolated from the culture broth of Streptomyces sp. KMF-004 from a solar saltern at Aphae Island, Korea. The structures of these salinazinones, which are unusual and consist of 2-methylpropenyl-1,3-oxazin-6-one bearing 1-oxopyrrolidinyl substituents, were assigned by spectral and chemical analyses using Mosher鈥檚 method, circular dichroism (CD), and calculated ECD. Salinazinones are the first examples of a natural alkaloid class composed of an oxazinone鈥損yrrolidone conjugate.