One-Pot Asymmetric Synthesis of Seven-Membered Carbocycles Cyclohepta[b]indoles via a Sequential Organocatalytic Michael/Double Friedel鈥揅rafts Alkylation Reaction
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- 作者：Nitin S. Dange ; Bor-Cherng Hong ; Chih-Ching Lee ; Gene-Hsiang Lee
- 刊名：Organic Letters
- 出版年：2013
- 出版时间：August 2, 2013
- 年：2013
- 卷：15
- 期：15
- 页码：3914-3917
- 全文大小：329K
- 年卷期：v.15,no.15(August 2, 2013)
- ISSN：1523-7052
文摘
A new method has been developed for the enantioselective synthesis of highly functionalized cyclohepta[b]indoles with high enantioselectivity (up to 96% ee). The process combines an enantioselective organocatalytic Michael addition and a highly efficient double Friedel鈥揅rafts reaction sequence in one pot with good yields and stereoselectivity. The structures and absolute configurations of the products were confirmed by X-ray analysis.