Secondary Metabolites from the Roots of Neolitsea daibuensis and Their Anti-inflammatory Activity

详细信息    查看全文

• 作者：Su-Ling Wong ; Hsun-Shuo Chang ; Guei-Jane Wang ; Michael Y. Chiang ; Hung-Yi Huang ; Chu-Huang Chen ; Shiow-Chwen Tsai ; Chu-Hung Lin ; Ih-Sheng Chen
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：December 27, 2011
• 年：2011
• 卷：74
• 期：12
• 页码：2489-2496
• 全文大小：356K
• 年卷期：v.74,no.12(December 27, 2011)
• ISSN：1520-6025

文摘

Bioassay-guided fractionation of the roots of Neolitsea daibuensis afforded three new 尾-carboline alkaloids, daibucarbolines A鈥揅 (1鈥?b>3), three new sesquiterpenoids, daibulactones A and B (4 and 5) and daibuoxide (6), and 20 known compounds. The structures of 1鈥?b>6 were determined by spectroscopic analysis and single-crystal X-ray diffraction. Daibucarboline A (1), isolinderalactone (7), 7-O-methylnaringenin (8), and prunetin (9) exhibited moderate iNOS inhibitory activity, with IC₅₀ values of 18.41, 0.30, 19.55, and 10.50 渭M, respectively.