Ruthenium-Catalyzed C–H Alkynylation of Aromatic Amides with Hypervalent Iodine–Alkyne Reagents

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• 作者：Ramadoss Boobalan ; Parthasarathy Gandeepan ; Chien-Hong Cheng
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：July 15, 2016
• 年：2016
• 卷：18
• 期：14
• 页码：3314-3317
• 全文大小：394K
• 年卷期：0
• ISSN：1523-7052

文摘

An efficient C–H activation method for the ortho alkynylation of aromatic N-methoxyamides with hypervalent iodine–alkyne reagent using a ruthenium catalyst is described. The reaction proceeds under mild reaction conditions with broad substrate scope. A possible catalytic cycle involving a ruthenium carboxylate assisted C–H bond cleavage is proposed from the preliminary mechanistic evidence.