Parvifloranines A and B, Two 11-Carbon Alkaloids from Geijera parviflora

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• 作者：Qingyao Shou ; Linda K. Banbury ; Dane E. Renshaw ; Joshua E. Smith ; Xiaoxiang He ; Ashley Dowell ; Hans J. Griesser ; Michael Heinrich ; Hans Wohlmuth
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：July 26, 2013
• 年：2013
• 卷：76
• 期：7
• 页码：1384-1387
• 全文大小：241K
• 年卷期：v.76,no.7(July 26, 2013)
• ISSN：1520-6025

文摘

Two novel alkaloids (parvifloranines A and B), possessing an unusual 11-carbon skeleton linked with amino acids, were isolated from Geijera parviflora, an endemic Australian Rutaceae. Their structures were elucidated by extensive spectroscopic measurements including 2D NMR analyses. Parvifloranine A was found to be a mixture of two enantiomers, (S)-1 and (R)-1, in a ratio of 1:4, based on their separation using a chiral column. Parvifloranine B is also believed to be a mixture of enantiomers. Proposed biosynthetic pathways are discussed. Parvifloranine A inhibited the synthesis of nitric oxide in LPS-stimulated RAW 264.7 macrophages with an IC₅₀ value of 23.4 渭M.