Concise Cu (I) Catalyzed Synthesis of Substituted Benzofurans via a Tandem SNAr/C–O Coupling Process

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• 作者：Zhiguo J. Song ; Lushi Tan ; Guiquan Liu ; Honglin Ye ; Jianming Dong
• 刊名：Organic Process Research & Development
• 出版年：2016
• 出版时间：June 17, 2016
• 年：2016
• 卷：20
• 期：6
• 页码：1088-1092
• 全文大小：286K
• 年卷期：0
• ISSN：1520-586X

文摘

A novel and convergent approach to tetrasubstituted benzofurans was developed from ortho-bromo aryl fluorides and keto-amides via one-pot SNAr displacement and subsequent Cu(I) catalyzed C–O coupling on the ortho-bromide. The scope of this methodology was demonstrated on several similar substrates.