Phenolic Compounds from Caesalpinia sappan Heartwood and Their Anti-inflammatory Activity

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• 作者：To Dao Cuong ; Tran Manh Hung ; Jin Cheol Kim ; Eun Hee Kim ; Mi Hee Woo ; Jae Sue Choi ; Jeong Hyung Lee ; Byung Sun Min
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：December 28, 2012
• 年：2012
• 卷：75
• 期：12
• 页码：2069-2075
• 全文大小：329K
• 年卷期：v.75,no.12(December 28, 2012)
• ISSN：1520-6025

文摘

Four new phenolic compounds, caesalpiniaphenols A鈥揇 (1鈥?b>4), together with eight known compounds were isolated from Caesalpinia sappan heartwood. The chemical structures were established mainly by NMR, MS, ECD, and Mosher鈥檚 method. Compounds 4, 5, and 7 showed weak inhibitory activity against the LPS-induced NO production in macrophage RAW264.7 cells with IC₅₀ values of 12.2, 3.5, and 5.7 渭M, respectively.