Dynamic Micropatterning of Cells on Nanostructured Surfaces Using a Cell-friendly Photoresist

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• 作者：SoonHo Kweon ; Kwang Hoon Song ; HyoungJun Park ; Jong-Cheol Choi ; Junsang Doh
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2016
• 出版时间：February 17, 2016
• 年：2016
• 卷：8
• 期：6
• 页码：4266-4274
• 全文大小：476K
• ISSN：1944-8252

文摘

Cellular dynamics under complex topographical microenvironments are important for many biological processes in development and diseases, but systematic investigation has been limited due to the lack of technology. Herein, we developed a new dynamic cell patterning method based on a cell-friendly photoresist polymer that allows in situ control of cell dynamics on nanostructured surfaces. Using this method, we quantitatively compared the spreading dynamics of cells on nanostructured surfaces to those on flat surfaces. Furthermore, we investigated how cells behaved when they simultaneously encountered two topographically distinct surfaces during spreading. This method will allow many exciting opportunities in the fundamental study of cellular dynamics.