Remodeling of Dynamic Structures of HIV-1 Envelope Proteins Leads to Synthetic Antigen Molecules Inducing Neutralizing Antibodies

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• 作者：Toru Nakahara ; Wataru Nomura ; Kenji Ohba ; Aki Ohya ; Tomohiro Tanaka ; Chie Hashimoto ; Tetsuo Narumi ; Tsutomu Murakami ; Naoki Yamamoto ; Hirokazu Tamamura
• 刊名：Bioconjugate Chemistry
• 出版年：2010
• 出版时间：April 21, 2010
• 年：2010
• 卷：21
• 期：4
• 页码：709-714
• 全文大小：229K
• 年卷期：v.21,no.4(April 21, 2010)
• ISSN：1520-4812

文摘

A synthetic antigen targeting membrane-fusion mechanism of HIV-1 has a newly designed template with C3-symmetric linkers mimicking N36 trimeric form. The antiserum produced by immunization of the N36 trimeric form antigen showed structural preference in binding to N36 trimer and stronger inhibitory activity against HIV-1 infection than the N36 monomer. Our results suggest an effective strategy of HIV vaccine design based on a relationship to the native structure of proteins involved in HIV fusion mechanisms.