Large Scale Preparation of Silicon-Functionalized SynPhase Polystyrene Lanterns for Solid-Phase Synthesis

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• 作者：Troy D. Ryba ; Kristopher M. Depew ; Lisa A. Marcaurelle
• 刊名：Journal of Combinatorial Chemistry
• 出版年：2009
• 出版时间：January 12, 2009
• 年：2009
• 卷：11
• 期：1
• 页码：110-116
• 全文大小：273K
• 年卷期：v.11,no.1(January 12, 2009)
• ISSN：1520-4774

文摘

The two-step functionalization of 30000 SynPhase Polystyrene (PS) Lanterns in a 30-L glass process reactor is described. The first step involves bromination of the polystyrene backbone to afford an aryl bromide handle. Subsequent Suzuki cross coupling with the trialkylborane generated in situ from the reaction of allyldiisopropyl(4-methoxyphenyl)silane and 9-BBN provided an alkylsilyl linker ready for loading of various alcohols for solid-phase synthesis applications.