Atmospheric Pressure Vaporization Mechanism for Coupling a Liquid Phase with Electron Ionization Mass Spectrometry

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• 作者：Veronica Termopoli ; Giorgio Famiglini ; Pierangela Palma ; Maurizio Piergiovanni ; Achille Cappiello
• 刊名：Analytical Chemistry
• 出版年：2017
• 出版时间：February 7, 2017
• 年：2017
• 卷：89
• 期：3
• 页码：2049-2056
• 全文大小：460K
• ISSN：1520-6882

文摘

A novel liquid chromatography–mass spectrometry (LC–MS) interfacing concept is presented and discussed. The new interface, called liquid-EI (LEI), is based on electron ionization (EI) but, differently from any previous attempt, the vaporization of solutes and mobile phase takes place at atmospheric pressure into a specifically designed region, called “vaporization microchannel”, before entering the high-vacuum ion source. The interface is completely independent from the rest of the instrumentation and can be adapted to any gas chromatography/mass spectrometry (GC/MS) system, as an add-on for a rapid LC–MS conversion. Pressure drop and temperature gradient between LC and MS were considered to enhance the analyte response and reduce band broadening and/or solute carryovers. A fused silica liner, placed inside the vaporization microchannel, acts as an inert vaporization surface speeding up the gas-phase conversion of large molecules while lessening possible memory effects. The liner is easily replaceable for a quick and extremely simple interface maintenance. Proof of concept and detailed description of the interface are here presented.