Palladium(II)-Catalyzed Coupling of Electron-Deficient Arenes via C鈥揌 Activation

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• 作者：Lihong Zhou ; Wenjun Lu
• 刊名：Organometallics
• 出版年：2012
• 出版时间：March 26, 2012
• 年：2012
• 卷：31
• 期：6
• 页码：2124-2127
• 全文大小：247K
• 年卷期：v.31,no.6(March 26, 2012)
• ISSN：1520-6041

文摘

Homocoupling and cross-coupling of electron-deficient arenes, including nitrobenzene, (trifluoromethyl)benzene, ethyl benzoate, etc., have been developed to afford biaryls using a catalytic system of Pd(OAc)₂/trifluoroacetic acid (TFA)/O₂ or K₂S₂O₈. The crucial step is to tune the concentrations of arenes and the loading of TFA carefully to enhance the reaction rates and the selectivity of these couplings involving dual C鈥揌 activation.