Hydrogenation of Aldehydes Catalyzed by an Available Ruthenium Complex
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- 作者：Xuefeng Tan ; Guozhen Wang ; Ziyue Zhu ; Conghui Ren ; Jinping Zhou ; Hui Lv ; Xiaoyong Zhang ; Lung Wa Chung ; Lina Zhang ; Xumu Zhang
- 刊名：Organic Letters
- 出版年：2016
- 出版时间：April 1, 2016
- 年：2016
- 卷：18
- 期：7
- 页码：1518-1521
- 全文大小：274K
- ISSN：1523-7052
文摘
A readily available ruthenium(II) catalyst was developed for the catalytic hydrogenation of aldehydes with a TON (turnover number) up to 340000. It can be performed without base and solvent, showing highly industrial potential. High chemoselectivity can be achieved in the presence of alkenyl and ketone groups. Further application of this protocol in glucose reduction showed good efficiency. Theoretical studies revealed that the rate-determining step is the hydrogenation step, not the carboxylate-assisted H2 activation step.