Melodinines M鈥揢, Cytotoxic Alkaloids from Melodinus suaveolens

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• 作者：Ya-Ping Liu ; Yan Li ; Xiang-Hai Cai ; Xing-Yao Li ; Ling-Mei Kong ; Gui-Guang Cheng ; Xiao-Dong Luo
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：February 24, 2012
• 年：2012
• 卷：75
• 期：2
• 页码：220-224
• 全文大小：241K
• 年卷期：v.75,no.2(February 24, 2012)
• ISSN：1520-6025

文摘

Nine new alkaloids, melodinines M鈥揢 (1鈥?b>9), and 11 known alkaloids were isolated from Melodinus suaveolens. The new structures were elucidated by extensive NMR and mass spectroscopic analyses and comparison to known compounds. All compounds were evaluated for their cytotoxicity against five human cancer cell lines. Compounds 6, 11, and 16 showed significant cytotoxicity.