Lingzhiols, Unprecedented Rotary Door-Shaped Meroterpenoids as Potent and Selective Inhibitors of p-Smad3 from Ganoderma lucidum
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- 作者：Yong-Ming Yan ; Jun Ai ; Li鈭扡i Zhou ; Arthur C.K. Chung ; Rong Li ; Jing Nie ; Ping Fang ; Xin-Long Wang ; Jie Luo ; Qun Hu ; Fan-Fan Hou ; Yong-Xian Cheng
- 刊名：Organic Letters
- 出版年：2013
- 出版时间：November 1, 2013
- 年：2013
- 卷：15
- 期：21
- 页码：5488-5491
- 全文大小：284K
- 年卷期：v.15,no.21(November 1, 2013)
- ISSN：1523-7052
文摘
(+)-Lingzhiol and (鈭?-lingzhiol, a pair of rotary door-shaped meroterpenoidal enantiomers, were isolated from Ganoderma lucidum. Their structures were identified by spectroscopic methods and X-ray diffraction crystallography. Lingzhiol bears an unusual 5/5/6/6 ring system characteristic of sharing a C-3鈥测€揅-7鈥?axis. Biological evaluation showed that (+)-lingzhiol or (鈭?-lingzhiol could selectively inhibit the phosphorylation of Smad3 in TGF-尾1-induced rat renal proximal tubular cells and activate Nrf2/Keap1 in mesangial cells under diabetic conditions.