Acyclic Stereoselective Boron Alkylation Reactions for the Asymmetric Synthesis of -Substituted 
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- 作者：Martin J. O'Donnell ; Jeremy T. Cooper ; and Mary M. Mader
- 刊名：Journal of the American Chemical Society
- 出版年：2003
- 出版时间：March 5, 2003
- 年：2003
- 卷：125
- 期：9
- 页码：2370 - 2371
- 全文大小：59K
- 年卷期：v.125,no.9(March 5, 2003)
- ISSN：1520-5126
文摘
Optically active syn- or anti-
-substituted-
-amino acid derivatives are prepared in 94 to 
99% ee and 66-98% ds by reaction of the Schiff base acetate of glycine tert-butyl ester with chiral, nonracemic B-alkyl-9-BBN derivatives in the presence of the Cinchona alkaloid, cinchonidine (CdOH) or cinchonine (CnOH), base, and lithium chloride.
-substituted--amino acid derivatives are prepared in 94 to 99% ee and 66-98% ds by reaction of the Schiff base acetate of glycine tert-butyl ester with chiral, nonracemic B-alkyl-9-BBN derivatives in the presence of the Cinchona alkaloid, cinchonidine (CdOH) or cinchonine (CnOH), base, and lithium chloride.