Copper-Catalyzed Direct Amination of Quinoline N-Oxides via C鈥揌 Bond Activation under Mild Conditions

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• 作者：Chongwei Zhu ; Meiling Yi ; Donghui Wei ; Xuan Chen ; Yangjie Wu ; Xiuling Cui
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：April 4, 2014
• 年：2014
• 卷：16
• 期：7
• 页码：1840-1843
• 全文大小：304K
• 年卷期：v.16,no.7(April 4, 2014)
• ISSN：1523-7052

文摘

A highly efficient and concise one-pot strategy for the direct amination of quinoline N-oxides via copper-catalyzed dehydrogenative C鈥揘 coupling has been developed. The desired products were obtained in good to excellent yields for 22 examples starting from the parent aliphatic amines. This methodology provides a practical pathway to 2-aminoquinolines and features a simple system, high efficiency, environmental friendliness, low reaction temperature, and ligand, additives, base, and external oxidant free conditions.