Cell Internalizable and Intracellularly Degradable Cationic Polyurethane Micelles as a Potential Platform for Efficient Imaging and Drug Delivery

详细信息    查看全文

• 作者：Mingming Ding ; Xin Zeng ; Xueling He ; Jiehua Li ; Hong Tan ; Qiang Fu
• 刊名：Biomacromolecules
• 出版年：2014
• 出版时间：August 11, 2014
• 年：2014
• 卷：15
• 期：8
• 页码：2896-2906
• 全文大小：749K
• ISSN：1526-4602

文摘

A cell internalizable and intracellularly degradable micellar system, assembled from multiblock polyurethanes bearing cell-penetrating gemini quaternary ammonium pendent groups in the side chain and redox-responsive disulfide linkages throughout the backbone, was developed for potential magnetic resonance imaging (MRI) and drug delivery. The nanocarrier is featured as a typical 鈥渃leavable core鈥搃nternalizable shell鈥損rotective corona鈥?architecture, which exhibits small size, positive surface charge, high loading capacity, and reduction-triggered destabilization. Furthermore, it can rapidly enter tumor cells and release its cargo in response to an intracellular level of glutathione, resulting in enhanced drug efficacy in vitro. The magnetic micelles loaded with superparamagnetic iron oxide (SPIO) nanoparticles demonstrate excellent MRI contrast enhancement, with T₂ relaxivity found to be affected by the morphology of SPIO-clustering inside the micelle core. The multifunctional carrier with good cytocompatibility and nontoxic degradation products can serve as a promising theranostic candidate for efficient intracellular delivery of anticancer drugs and real-time monitoring of therapeutic effect.