Vibrational Circular Dichroism Shows Reversible Helical Handedness Switching in Peptidomimetic l-Valine Fibrils

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• 作者：Bel茅n Nieto-Ortega ; Vicent J. Nebot ; Juan F. Miravet ; Beatriu Escuder ; Juan T. L贸pez Navarrete ; Juan Casado ; Francisco J. Ram铆rez
• 刊名：The Journal of Physical Chemistry Letters
• 出版年：2012
• 出版时间：August 16, 2012
• 年：2012
• 卷：3
• 期：16
• 页码：2120-2124
• 全文大小：357K
• 年卷期：v.3,no.16(August 16, 2012)
• ISSN：1948-7185

文摘

We elucidate the supramolecular organization in the form of microsize fibrils of gels formed by a l-Valine peptidomimetic compound. Analysis was based on circular dichroism spectroscopies, vibrational (VCD) and electronic (CD), supported by microscopy (atomic force and scanning electron). We show how the VCD spectra give account of the micrometric structure of the fibrils formed by the helicoidal arrangement of simpler proto-fibrils, which are organized in a lower hierarchical level. This ability is used to monitorize a fully reversible change in the handedness of the helix by modulating different external stimuli as pH or ionic strength, thus providing the first observation by VCD of such a phenomenon in a short peptide.

Keywords:

f="http://pubs.acs.org/action/doSearch?action=search&searchText=circular+dichroism&qsSearchArea=searchText">circular dichroism; f="http://pubs.acs.org/action/doSearch?action=search&searchText=microscopy&qsSearchArea=searchText">microscopy; f="http://pubs.acs.org/action/doSearch?action=search&searchText=hydrogel&qsSearchArea=searchText">hydrogel; f="http://pubs.acs.org/action/doSearch?action=search&searchText=chirality&qsSearchArea=searchText">chirality; f="http://pubs.acs.org/action/doSearch?action=search&searchText=peptidomimetic&qsSearchArea=searchText">peptidomimetic