An Unsymmetrical Approach to the Synthesis of Bismethylene Triphosphate Analogues

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• 作者：Scott D. Taylor ; Farzad Mirzaei ; Stephen L. Bearne
• 刊名：Organic Letters
• 出版年：2006
• 出版时间：September 14, 2006
• 年：2006
• 卷：8
• 期：19
• 页码：4243 - 4246
• 全文大小：76K
• 年卷期：v.8,no.19(September 14, 2006)
• ISSN：1523-7052

文摘

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A protected, unsymmetrical bismethylene triphosphate analogue was prepared by sequential Michaelis-Arbuzov reactions on ethylbis(halomethyl)phosphinates. This species was monodeprotected at one of the terminal phosphonate groups in high yield. The resultingmonodeprotected compound was used to achieve the first syntheses of the bismethylene triphosphate analogues of UTP and CTP.