Antiproliferative Limonoids of a Malleastrum sp. from the Madagascar Rainforest
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- 作者：Brian T. Murphy ; Peggie Brodie ; Carla Slebodnick ; James S. Miller ; Chris Birkinshaw ; Lucien M. Randrianjanaka ; Rabodo Andriantsiferana ; Vincent E. Rasamison ; Karen TenDyke ; Edward M. Suh ; David G. I. K
- 刊名：Journal of Natural Products
- 出版年：2008
- 出版时间：March 2008
- 年：2008
- 卷：71
- 期：3
- 页码：325 - 329
- 全文大小：512K
- 年卷期：v.71,no.3(March 2008)
- ISSN：1520-6025
文摘
Bioassay-guided fractionation of an ethanol extract of a Malleastrum sp. afforded three new limonoids, malleastrones A−C (1−3), respectively. Each limonoid contained a rare tetranortriterpenoid skeleton. Structure elucidation of the isolates was carried out by analysis of one- and two-dimensional NMR and X-ray diffraction data. The novel isolates 1 and 2 were tested for antiproliferative activity against a panel of cancer cell lines and exhibited IC50 values ranging from 0.19 to 0.63 µM.