Cycloartane Triterpenes Isolated from Combretum quadrangulare in a Screening Program for Death-Receptor Expression Enhancing Activity

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• 作者：Kazufumi Toume ; Takafumi Nakazawa ; Takashi Ohtsuki ; Midori A. Arai ; Takashi Koyano ; Thaworn Kowithayakorn ; Masami Ishibashi
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：February 25, 2011
• 年：2011
• 卷：74
• 期：2
• 页码：249-255
• 全文大小：822K
• 年卷期：v.74,no.2(February 25, 2011)
• ISSN：1520-6025

文摘

In our screening program for natural products that increase DR5 (death-receptor 5) expression, nine new cycloartane triterpenes, combretanones A鈭扜 (1鈭?b>7), combretic acid A (8), and combretic acid B (9), were isolated from a MeOH extract of Combretum quadrangulare leaves. The known oleanane triterpenes (10, 11) and six known flavonols (12鈭?b>17) were also isolated. The structures of 1鈭?b>9 were elucidated by spectroscopic studies. Compounds 7, 9, 12, 16, and 17 enhanced DR5 expression, and 16 showed TRAIL-resistance abrogating activity.