Biocatalytic Promiscuity of Lipase in Chemoselective Oxidation of Aryl Alcohols/Acetates: A Unique Synergism of CAL-B and [hmim]Br for the Metal-Free H2O2 Activation
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- 作者：Upendra K. Sharma ; Nandini Sharma ; Rakesh Kumar ; Rajesh Kumar ; Arun K. Sinha
- 刊名：Organic Letters
- 出版年：2009
- 出版时间：November 5, 2009
- 年：2009
- 卷：11
- 期：21
- 页码：4846-4848
- 全文大小：183K
- 年卷期：v.11,no.21(November 5, 2009)
- ISSN：1523-7052
文摘
A unique synergistic combination of lipase and ionic liquid [hmim]Br is reported for metal-free H2O2 activation, which is the first example of biocatalytic promiscuity of CAL-B for chemoselective oxidation of aryl alcohols/acetates. The catalytic system exhibits excellent functional group compatibility under neutral conditions besides reusability up to ten cycles thereby making the process economically and environmentally viable.