Constituents of the Rhizomes of Boesenbergia pandurata and Their Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Line
详细信息 查看全文
- 作者：Nhan Trung NguyenMai Thanh Thi Nguyen ; Hai Xuan Nguyen ; Phu Hoang DangDya Fita Dibwe ; Hiroyasu Esumi ; Suresh Awale
- 刊名：Journal of Natural Products
- 出版年：2017
- 出版时间：January 27, 2017
- 年：2017
- 卷：80
- 期：1
- 页码：141-148
- 全文大小：449K
- ISSN：1520-6025
文摘
Human pancreatic cancer cell lines have a remarkable tolerance to nutrition starvation, which enables them to survive under a tumor microenvironment. The search for agents that preferentially inhibit the survival of cancer cells under low nutrient conditions represents a novel antiausterity strategy in anticancer drug discovery. In this investigation, a methanol extract of the rhizomes of Boesenbergia pandurata showed potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrient-deprived conditions, with a PC50 value of 6.6 μg/mL. Phytochemical investigation of this extract led to the isolation of 15 compounds, including eight new cyclohexene chalcones (1–8). The structures of the new compounds were elucidated by NMR spectroscopic data analysis. Among the isolated compounds obtained, isopanduratin A1 (14) and nicolaioidesin C (15) exhibited potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived conditions, with PC50 values of 1.0 and 0.84 μM, respectively.