Anticarcinogenic Activity of Selenium-Enriched Green Tea Extracts in Vivo

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• 作者：Juan Xu ; Fangmei Yang ; Xinxin An ; Qiuhui Hu
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2007
• 出版时间：June 27, 2007
• 年：2007
• 卷：55
• 期：13
• 页码：5349 - 5353
• 全文大小：199K
• 年卷期：v.55,no.13(June 27, 2007)
• ISSN：1520-5118

文摘

Both selenium and green tea have been shown to have potential antitumor effects. Here we haveinvestigated the anticarcinogenic effect of the selenium-enriched green tea extract (Se-TE) in aKunming mice model transplanted with human hepatoma cells HepG2. Mice were assigned to 8groups consisting of 10 mice each after tumor cell inoculation. The control group received only water,whereas the remaining groups received regular green tea extract (RT), Se-TE which was producedby fertilization with selenite on tea leaves, selenite, and RT + selenite. After the mice were fedintragastrically with these agents for 8 days, tumor growth in RT-, Se-TE-, and selenite-fed mice wassignificantly suppressed, compared with that in control mice (P < 0.001). Supplementation with Se-TEs and selenite was able to elevate mice blood and liver Se concentrations, but did not significantlyenhance selenoprotein glutathione peroxidase and other antioxidant enzyme superoxide dismutaseactivity in mice blood and liver. These results suggest that the antitumor function of Se-TEs may beattributed to the oxidative stress induced by selenium and green tea components in a suitable seleniumsupplementation pathway.