Palladium/l-Proline-Catalyzed Enantioselective α-Arylative Desymmetrization of Cyclohexanones

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• 作者：Ren-Rong Liu ; Bao-Le Li ; Jun Lu ; Chong Shen ; Jian-Rong Gao ; Yi-Xia Jia
• 刊名：Journal of the American Chemical Society
• 出版年：2016
• 出版时间：April 27, 2016
• 年：2016
• 卷：138
• 期：16
• 页码：5198-5201
• 全文大小：430K
• 年卷期：0
• ISSN：1520-5126

文摘

A highly enantioselective palladium/l-proline-catalyzed α-arylative desymmetrization of cyclohexanones was developed. The new strategy for α-arylation reaction led to a series of optically active morphan derivatives bearing α-carbonyl tertiary stereocenters in good yields with excellent enantioselectivities (up to 99% ee).