Complex Polycyclic Scaffolds by Metathesis Rearrangement of Himbert Arene/Allene Cycloadducts

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• 作者：Jonathan K. Lam ; Yvonne Schmidt ; Christopher D. Vanderwal
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：November 2, 2012
• 年：2012
• 卷：14
• 期：21
• 页码：5566-5569
• 全文大小：282K
• 年卷期：v.14,no.21(November 2, 2012)
• ISSN：1523-7052

文摘

The intramolecular arene/allene cycloaddition first described 30 years ago by Himbert and Henn permits rapid access to strained polycyclic compounds. Alkene metathesis processes cleanly rearrange appropriately substituted cycloadducts into complex, functional-group-rich polycyclic lactams of potential utility for natural product synthesis and medicinal chemistry.