Ruthenium-Catalyzed One-Pot -Alkylation of Secondary Alcohols with Primary Alcohols

详细信息    查看全文

• 作者：Chan Sik Cho ; Bok Tae Kim ; Hong-Seok Kim ; Tae-Jeong Kim ; and Sang Chul Shim
• 刊名：Organometallics
• 出版年：2003
• 出版时间：August 18, 2003
• 年：2003
• 卷：22
• 期：17
• 页码：3608 - 3610
• 全文大小：72K
• 年卷期：v.22,no.17(August 18, 2003)
• ISSN：1520-6041

文摘

Secondary alcohols (carbinols) react withprimary alcohols in dioxane at 80 C in the presence ofa catalytic amount of RuCl₂(PPh₃)₃ and KOH along witha sacrificial hydrogen acceptor to afford the corresponding coupled secondary alcohols. The reaction is applicable to a wide range of aryl methyl, alkyl methyl,and cyclic carbinols, and with alkyl methyl carbinols,the alkylation took place exclusively at the less-hinderedmethyl position over -methylene and -methine.