Synthesis of Oligodeoxynucleotides Containing Electrophilic Groups

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• 作者：Xi Lin ; Jinsen Chen ; Shahien Shahsavari ; Nathanael Green ; Deepti Goyal ; Shiyue Fang
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：August 5, 2016
• 年：2016
• 卷：18
• 期：15
• 页码：3870-3873
• 全文大小：372K
• 年卷期：0
• ISSN：1523-7052

文摘

By use of 1,3-dithian-2-yl-methoxycarbonyl (Dmoc) as a protecting group and linker for oligodeoxynucleotide (ODN) synthesis, deprotection and cleavage are achieved under non-nucleophilic oxidative conditions. The nucleophile-sensitive thioester and α-chloroacetyl groups are conveniently incorporated into ODN sequences. The technology could be universally useful for electrophilic ODN synthesis.