Multifunctional Hydroxyapatite/Na(Y/Gd)F4:Yb3+,Er3+ Composite Fibers for Drug Delivery and Dual Modal Imaging

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• 作者：Min Liu ; Hui Liu ; Shufen Sun ; Xuejiao Li ; Yanmin Zhou ; Zhiyao Hou ; Jun Lin
• 刊名：Langmuir
• 出版年：2014
• 出版时间：February 4, 2014
• 年：2014
• 卷：30
• 期：4
• 页码：1176-1182
• 全文大小：484K
• ISSN：1520-5827

文摘

Porous hydroxyapatite (HAp) composite fibers functionalized with up-conversion (UC) luminescent and magnetic Na(Y/Gd)F₄:Yb³⁺,Er³⁺ nanocrystals (NCs) have been fabricated via electrospinning. After transferring hydrophobic oleic acid-capped Na(Y/Gd)F₄:Yb³⁺,Er³⁺ NCs into aqueous solution, these water-dispersible NCs were dispersed into precursor electrospun solution containing CTAB. Na(Y/Gd)F₄:Yb³⁺,Er³⁺@HAp composite fibers were fabricated by the high temperature treatment of the electrospun Na(Y/Gd)F₄:Yb³⁺,Er³⁺ NCs decorated precursor fibers. The biocompatibility test on MC 3T3-E1 cells using MTT assay shows that the HAp composite fibers have negligible cytotoxity, which reveals the HAp composite fibers could be a drug carrier for drug delivery. Because the contrast brightening is enhanced at increased concentrations of Gd³⁺, the HAp composite fibers can serve as T₁ magnetic resonance imaging contrast agents. In addition, the composites uptaken by MC 3T3-E1 cells present the UC luminescent emission of Er³⁺ under the excitation of a 980 nm near-infrared laser. The above findings reveal Na(Y/Gd)F₄:Yb³⁺,Er³⁺@HAp composite fibers have potential applications in drug storage/release and magnetic resonance/UC luminescence imaging.